Noise Stress Impairs Prefrontal Cortical Cognitive Function in Monkeys

Prefrontal cortical blood flow and cognitive function in Huntington's disease.

To examine the relationship between cortical physiology and dementia in Huntington's disease, rCBF during three different behavioural conditions, one of which emphasised prefrontal cognition, was determined by xenon-133 inhalation in 14 patients with Huntington's disease and in matched controls. Cortical rCBF was not reduced in Huntington's disease patients even while they manifested overt pref...

A role for PKC in mediating stress-induced prefrontal cortical structural plasticity and cognitive function.

I mpaired cognitive functioning plays an important role in several major psychiatric illnesses, including schizophrenia and bipolar disorder (BPD) (1, 2). Cognitive impairments can also appear before full-blown onset of illness (3) and affect key components of course and recovery, including illness progression, functional outcome, disability, and quality of life. Considerable interest therefore...

Neural mechanisms of prefrontal cortical function: implications for cognitive rehabilitation.

Understanding the role of the frontal lobes in cognition remains a challenge for neurologists and neuroscientists. It is proposed that goal-directed behavior, at the core of what we consider human, depends critically on the function of the frontal lobes, and, specifically, the prefrontal cortex (PFC). In this chapter, we put forth the hypothesis that further insight into the neural mechanisms u...

Endogenous glucocorticoids are essential for maintaining prefrontal cortical cognitive function.

Glucocorticoid hormones are important in the maintenance of many brain functions. Although their receptors are distributed abundantly throughout the brain, including the prefrontal cortex (PFC), it is not clear how glucocorticoid functions, particularly with regard to cognitive processing in the PFC. There is evidence of PFC cognitive deficits such as working memory impairment in several stress...

Chronic Stress Effects on Prefrontal Cortical Structure and Function